Simultaneous Qualitative and Quantitative Study of Main Compounds in Commelina communis Linn. by UHPLC–Q-TOF-MS-MS and HPLC–ESI-MS-MS

Qualitative and Quantitative Analysis of the Major Constituents in Shexiang Tongxin Dropping Pill by HPLC-Q-TOF-MS/MS and UPLC-QqQ-MS/MS.

Shexiang Tongxin dropping pill (STP) is a traditional Chinese medicine formula that consists of total saponins of ginseng, synthetic Calculus bovis, bear gall, Venenum bufonis, borneol and Salvia miltiorrhiza. STP has been widely used in China and Southeast Asia for the treatment of cardiovascular diseases. In this study, a qualitative analytical method using high performance liquid chromatogra...

Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS

A rapid and sensitive ultrafast performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS) was developed for the simultaneous determination of 11 compounds in Gualou Guizhi Granule (GLGZG), including liquiritin, isoliquiritin, liquirtin apioside, isoliquiritin apioside, liquiritigenin, isoliquiritigenin, glycyrrhizic acid, glycyrrhetinic acid, paeoniflorin, albiflorin, and p...

Use of Soft and Hard Ms Ionization Techniques for Unknown Compounds Elucidation by Gc-tof Ms

Investigation of trace level non-target compounds by GC-MS often is a challenging task that requires powerful software tools to detect the unknown components, to obtain the deconvoluted mass spectra, and to interpret the data if no acceptable library match is obtained. In this paper, the complementary use of EI and CI is investigated in combination with GCTOF MS for the elucidation of organic n...

Phytochemical analysis of Cyperus rotundus hexane fraction by GC-MS and total oligomeric flavonoid fraction by 4D GCXGC TOF-MS

Cyperus rotundus (CR) is a traditional medicinal herb, and recent studies demonstrated its pharmacological effects to cure neurological disorders. In our earlier reports, we also found that CR exerts anxiolytic effects and improves memory impairment in hypoxia-induced rats. In vitro CR also effectively ameliorates oxidative stress-induced SH-SY5Y neuronal cell damage. In the present study, we e...

HPLC-MS/MS of Highly Polar Compounds